Կենսաբանության ֆակուլտետ
Faculty of Biology
Faculty of Biology of Yerevan State University has been established in 1933. :
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Karine S. Matinyan

Associate Professor | Chair of Biophysics
Education
1974 - 1977: Ph.D. Student, Institute of Biophysics, Academy of Sciences, USSR
1968 - 1973: Graduate Student, Department of Biophysics, Faculty of Biology Yerevan State University

Academic degree
PhD

Professional experience
1978 - 1987: Junior Researcher, Department of Biophysics, Faculty of Biology, Yerevan State University
1987 - 2001: Researcher, Department of Biophysics, Faculty of Biology, Yerevan State University
2001 - 2005: Senior Researcher, Department of Biophysics, Faculty of Biology, Yerevan State University
2005 - 2011: Senior Researcher, Research laboratory "Biophysics of subcellular structures"
2012 jan 1 - present: Senior Researcher, Joint Research laboratory "Structural biophysics"

Academic courses
  • Radiobiology and radiobiophysics
  • Molecular and cellular biology
  • Biophysics
  • Modern conceptions of natural sciences
  • Biophysics of radiation damage
  • Energy migration and electron transport in biosystems

    Scale of professional interests
    Cellular biology, Biophysics, Biochemistry, Molecular endocrinology

    Participation in grant projects
    Armenian National Science and Education Fund (ANSEF) Biochem-3711, Age- and sex-dependent differences in inhibition of poly(ADP-ribos)yl polymerase 1 in thymocyte and liver nuclei after treatment of rats with cisplatin, 2015.
    Armenian National Science and Education Fund (ANSEF), Biochem-4182, The effect of the co-treatment with hydrocortisone and cisplatin on poly(adp-ribose)polymerase 1 activity in rat liver cells ”, 2016

    Languages
    Armenian (native), Russian, English

    karine.matinyan@ysu.am
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    Latest Publications (41)
    Effect of co-treatment of rats with cisplatin and tannic acid on substances involved in poly (ADP-ribose) polymer turnover in rat liver nuclei Effect of co-treatment of rats with cisplatin and tannic acid on substances involved in poly (ADP-ribose) polymer turnover in rat liver nuclei
    2021 | Thesis
    45th FEBS congress: Molecules of life: Towars new horizons, 03-08.07.2021, p. 137-138, Slovenia
    Изменение эффективности ингибиторов поли(адф-рибозо)полимеразы 1 в ядрах клеток печени крыс после IN VIVO действия цисплатина
    2019 | Article
    Евразийский Союз Учёных, 2019, 2(59), 3, стр. 7-10
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    Treatment of Rats With Tannic Acid Modulates Poly(ADP-Ribose) Polymerase 1 Activity in Liver and Thymocyte Nuclei
    2019 | Article
    International Journal of Pharmaceutical Sciences Review and Research, 2019, 56(1), pp. 89-95
    |
    Transient decondensation of chromatin in liver nuclei of rats treated with tannic acid
    2019 | Article
    Journal of biomolecular structure & dynamics. 2019, 37, pp. 1-7
    |
    Modulation of poly(ADPribose) polymerase 1 activity and chromatin condensation in thymocyte and liver nuclei after treatment of rats with tannic acid
    2019 | Thesis
    The 44th FEBS congress: From molecules to living systems. 2019, P37-003
    The Influence of Hydrocortizone and Cisplatin Co-Administration to Rats on Chromatin Olygonucleosomal Fragmentation in Liver Nuclei
    2019 | Thesis
    Albany 2019: 20th Conversation. 2019, p. 18988
    Karine S. Matinyan , Anush L. Asatryan, Arshak A. Karapetyan, Emil S. Gevorgyan
    Sex-Dependent Differences in Poly(ADP-Ribose)Polymerase 1 Activity of Rat Liver and Thymocyte Nuclei
    2019 | Thesis
    Albany 2019: 20th Conversation. 2019, p. 19010
    The Effect of Tannic Acid on PARP 1 Activity and Chromatin Condensation in Rat Thymocyte and Liver Nuclei
    2019 | Thesis
    Albany 2019: 20th conversation. 2019, p. 18995
    Effect of Insulin on DNA-Internucleosomal Fragmentation and Poly(ADP-ribose)polymerase 1 Activity in Rat Liver Nuclei
    2019 | Thesis
    Albany 2019: 20Th Conversation. 2019, p. 19011
    Poly(ADP-RIBOSE)polymerase 1 stimulation in liver and thymocyte nuclei of rats treated with benzamide
    2018 | Article
    International Journal of Pharmaceutical Sciences Review and Research, 2018, 52,1, pp. 15-19
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    Treatment of Rats with Hydrocortisone and Cisplatin Modulates Poly(ADP-Ribos)yl Polymerase 1 Activity In Liver and Thymocyte Nuclei
    2018 | Article
    International Journal of Pharmaceutical Sciences Review and Research. 2018, 50(2), 7-10 pp.
    |
    Возрастные oсобенности действия цисплатина на активность поли(АДФ-рибозо)полимеразы 1 в ядрах клеток печени крыс
    2016 | Thesis
    20-я Международная Пущинская Школа-Конференция Молодых Ученых «Биология - Наука XXI Века». 2016, p. 169
    |
    Cisplatin Modulates Poly(ADP-ribos)ylpolymerase 1 Inhibition and DNA Internucleosomal Fragmentation in Rat Liver Nuclei
    2016 | Article
    International Journal of Pharmaceutical Sciences Review and Research, 2016, 39(2), 25-30 pp
    |
    Cisplatin Modulates poly(adp-ribosyl) Polymerase 1 Inhibition and DNA Internucleosomal Fragmentation in Rat Liver Nuclei
    2016 | Article
    International Journal of Pharmaceutical Sciences Review and Research, 2016, 39(2), 25-30 pp.
    |
    Действие цисплатина на интенсивность интернуклеосомальной фрагментации ДНК в ядрах клеток печени крыс
    2015 | Article
    IV Международная научно-практическая конференция "Актуальные проблемы науки XXI века, 2015-11-21, 9-14 стр.
    |
    Age- And Sex-Dependent Modification Of The Activity And Inhibition Of Poly(ADP-Ribose)Polymerase 1 By Cisplatin In The Rat Thymocytes
    2015 | Article
    International Journal of Chemical and Biomedical Science. USA, 2015, 1, 5, 103-108 pp.
    |
    I. G. Artsruni , K. S. Matinyan , A. V. Margaryan, A. L. Asatryan, E. S. Gevorgyan
    Gender dependent differences in poly(ADP-ribose)polymerase-1 activity of rat liver and thymocyte nuclei
    2013 | Article
    Biolog. Journal of Armenia, 2013, v. 65, #4, p. 20-25.
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    I. G. Artsruni , K. S. Matinyan , A. L. Asatryan , A. V. Margaryan , E. S. Gevorgyan
    Cisplatin Alters Chromatin Structure And Suppress Poly(ADP-ribos)yl polymerase Activity in Rat Liver Nucei
    2013 | Thesis
    Book of Abstracts, International Conference “Physical Concepts Of Nucleic–Acid Structure And Behavior”, 2013, Yerevan, p. 43-44.
    Alterations of DNA internucleosomal fragmentation and PARP-1 activity in rat liver nuclei induced by hydrocortisone and insulin
    2011 | Thesis
    Сборник статей II Международной научно-практической конференции “Высокие технологии, фундаментальные и прикладные исследования в физиологии, фармакологии и медицине”, 2011, Санкт-Петербург, стр. 125-126.
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    Значение НАД+ и АТФ в переключении программ клеточной гибели
    2011 | Thesis
    Сборник статей II Международной научно-практической конференции “Высокие технологии, фундаментальные и прикладные исследования в физиологии, фармакологии и медицине”, 2011, Санкт-Петербург, стр. 68-69.
    |
    М. А. Мельникова-Шарова, И. Г. Арцруни , К. С. Матинян , Э. Г. Саркисян, Э. С. Геворкян
    Действие цисплатина на морфологические и гистохимические изменения в печени крыс
    2011 | Thesis
    Сборник тезисов 15-ой международной Пущинской школы-конференции молодых ученых, Пущино, 2011, с. 104.
    Effects of hydrocortisone and insulin on DNA internucleosomal fragmentation in rat thymocyte nuclei
    2011 | Article
    Biolog.J.Armenia, 2011, v. 63, #1, p. 51-55
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    Changes in chromatin conformation and parp-1 activity induced by cisplatin in rat liver
    2009 | Thesis
    Book of abstracts Albany 2009: The 16th conversation, June 16–20 2009. Journal of biomolecular structure and dynamics, volume 26, issue # 6, i-932, p. 905
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    Cisplatin Recovers Glucocorticoid-Induced DNA Condensation in Rat Liver Nuclei
    2008 | Thesis
    Proceedings of International Conference “Frontiers in Cancer Prevention Research”, Washington, DC, 2008, p.146
    The effect of insulin on chromatin internucleosomal cleavage in rat liver nuclei
    2008 | Article
    Biolog. Journ. Armenia, 1 (60), 2008‚ рр. 6-11
    Spontaneous internucleosomal DNA fragmentation is isolated nuclei
    2008 | Article
    Electronic journal of natural sciences, 2008, v. 10, #1, p. 12-18
    |
    Կ. Ս. Մատինյան , Ի. Գ. Արծրունի , Մ. Ա.Մելնիկովա-Շարովա
    Ինսուլինի ազդեցությունը քրոմատինի ինտերնուկլեոսոմային ճեղքավորման վրա առնետների լյարդի բջջակորիզներում
    2008 | Article
    Հայաստանի կենսաբ. հանդես, 2008, հ. 60, #3, էջ 6-11
    |
    Activation of Poly(ADP-ribosyl) polymerase of isolated rat liver in internucleosomal DNA fragmentation
    2007 | Thesis
    Journal of biomolecular structure and dynamics, Albany, USA, 2007, The 15th conversation, p. 753
    Մոլեկուլային և բջջային կենսաբանության մեթոդների համառոտ ակնարկ
    2006 | Book
    Լաբորատոր աշխատանքների ձեռնարկ, Երևան, 2006
    Hydrocortisone action on internucleosomal dna fragmentation in rat liver nuclei
    2006 | Article
    Electronic journal of natural sciences, Jan2005, Vol2005, Issue 1, p.8-12
    Effect of insulin on rat liver nuclear membrane polyphosphoinositide composition
    2004 | Article
    Vestnik MANEB, 2004, 9(8), p.195-198
    Действие инсулина на состав полифосфоинозитидов ядерных мембран клеток печени крыс
    2004 | Article
    Вестник МАНЭБ, 2004, т. 9, но 8, стр. 191-194
    Действие инсулина на состав полифосфоинозитидов ядерных мембран клеток печени крыс
    2004 | Article
    Вестник МАНЭБ, 2004, т. 9, но 8, стр. 191-194
    Modulation of DNA fragmentation induced by NAD+
    2003 | Article
    Electronic journal of national sciences, Nov2003, Vol2003, Issue 1, pp 4-7
    E.S. Gevorkyan , L. O. Demirkhanyan, K. S. Matinyan , S. A. Gonyan
    Electrokinetic potential of hepatocyte nuclei under the action of hydrocortisone and insulin
    2001 | Article
    Biophysics, 2001, Vol. 46, No. 1, pp. 144-146
    Estradiol effect on the electrokinetic potential of the rat brain synaptosomes
    1998 | Article
    Journal "Biophysics", 1998, Vol.43, N6, pp 982-984
    К.С. Матинян , Л.И. Агаджанов, Л.С. Асатрян, С.М. Мартиросов
    Изменения в системах транспорта лизина у Corynebacterium glutamicum
    1989 | Article
    Биотехнология, 1989, т.5, ¹6, с. 705-709
    К.С. Матинян , Э.С. Геворкян, А.Ш. Абрамян, Г.А.Паносян
    Изучение состава лабильносвязанных негистоновых белков хроматина печени петушков при воздействии эстрадиола
    1985 | Article
    Вопросы мед.химии 1985, т.31, ¹5, с.107-110
    К.С. Матинян , А.О. Вардеванян , Э.С. Геворкян, Р.Р. Вардапетян, Г.А.Паносян
    Исследование изменений в хроматине печени крыс при воздействии гидрокортизона
    1984 | Article
    Вопросы мед.химии 1984, т.30, ¹3, с. 116-120
    K.S. Matinyan , S.R. Umansky, V.I. Tokarskaya
    Polypeptide-synthesizing activity of eukaryotic chromatin
    1980 | Article
    Properties, de-pendence on poly(ADP-ribose) and connection with the cell cycle. Eur. J. Biochem, 1980, vol.105, pp.117-129
    К.С. Матинян , С.Р. Уманский
    Полипептидсинтетазная активность хроматина клеток эукариотов
    1978 | Article
    Биохимия, 1978, т.43, ¹7, с. 1196-1205