Կենսաբանության ֆակուլտետ
Faculty of Biology
Faculty of Biology of Yerevan State University has been established in 1933. :
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Susanna G. Tiratsuyan

Assistant | Faculty of Biology
Education
1970-1975 Yerevan State University, Biological Faculty, Department of Biophysics, Diploma of Honor, Yerevan
1976-1980 PhD student of Yerevan State University, Biological Faculty, Department of Biophysics.

Academic degree
Candidate of Biological sciences, PhD theme: “Effect of gibberellin and other biological active substances on a chromatin and activity of some germinating wheat germs enzymes” 4th of July, 1984, YSU council

Professional experience
1975 - present Scientific researcher in group of “Molecular Biophysics Laboratory” in Yerevan State University, Biological Faculty, Department of Biophysics.
1975 - 1977 - Charencavan institute of amino acid
March – April, 1980 - academic mission in Molecular oncology institute of Vien University, Austria
2007 - present – assistant, Yerevan State University, Biological Faculty, Department of Biophysics.
2008 – present - associate professor Russian-Armenian University, Medical-biology faculty

Academic courses
Modern research methods
Cell Engineering
Biophysics’ actual problems

Scale of professional interests
Investigation of molecular-cell mechanisms of action of selected herbal extracts and particular biological active components that collectively provoke a variety of physiological responses, have a wide range of medicinal applications, including cancerogenesis, atherogenesis, inflammations, neurodegeneration, autoimmune pathologies, viral/retro and bacterial diseases, progeria, skin wounds, eczema, burns, psychological disorders etc. Investigation of several classes of compounds common to most plants, including polyphenolics, flavonoids (quercetin, rutin), etc, as well as two very active classes of unique constituents – the phloroglucinols (hyperforin, adhyperforin) and the naphthodianthrones (hypericin, pseudohypericin). Hence, therapy using free-radical scavenging antioxidants has potential to prevent, delay or ameliorate many of disorders. Determination of the natural antioxidant compounds of plant extracts will help to develop new drug candidates for antioxidant therapy.
Models – chemical system (DPPH stable radical) and biological – red blood cells, hemoglobin, hemolysis, plant cell and tissue cultures, microorganisms, rats.
The aim of current work was to elucidate in vitro and in vivo different biological activities of various extracts, e.g. cytotoxic, photodynamic and free radical scavenging activities, determine the relationship of flavonoids composition, antiradical, antimicrobial and antihemolytic activities in chemical and biological systems; to examine the influence of HY on structure and function of Hb; evaluation of red blood cells as model system for screening of hypericin efficacy as a photodynamic agent.

Participation in grant projects (present and past)
• 1993 - One-off Soros grant
• 2003 - Involved in Armenian National Science and Educational Fundation (ANSEF) Grant Programme (NS-82) , Supervisor Dr., Prof. H. Vardapet¬yan, Yerevan, Armenia

Languages
Armenian, Native
English, Good
Russian, Fluent
French – with dictionary

(+374 10) 24-16-06

Latest Publications (26)
Vardapetyan H.R., Martirosyan A.S., Tiratsuyan S.G. , Hovhannisyan A.A.
Investigation of the interaction of hypericin with albumin
2010 | Article
Proc. of Int. Conf. “Biotechnology and Health-4”, Oct. 28-30, 2010, p.77-82
Martirosyan A.S., Vardapetyan H.R., Tiratsuyan S.G. , Hovhannisyan A.A.
Possibility of improvement of hemoglobin properties as biosensors’ detection element
2010 | Article
Proc. SPIE, Vol. 7715, Biophotonics: Photonic Solutions for Better Health Care II, Proceedings of SPIE Vol. 7715 (SPIE, Bellingham, WA, 2010) 77153N, p.77153N-1 – 77153N-8. doi:10.1117/12.852765
Vardapetyan H.R., Martirosyan A.S., Tiratsuyan S.G. , Hovhannisyan A.A.
Interaction between hypericin and hemoglobin
2010 | Article
J. Photochem. Photobiol. B: Biol. 2010, 101 p.53-58
Vardapetyan H.R., Tiratsuyan S.G. , Hovhannisyan A.A., Martirosyan A.S.
Effect of additives on photoinduced by hypericin and H. perforatum extracts erythrocyte destruction
2009 | Article
Scientific-practical J. Blood, №1 (9), 2009, p.31-37
Vardapetyan H.R., Tiratsuyan S.G. , Hovhannisyan A.A., Martirosyan A.S.
Influence of various components of H. perforatum extracts on erythrocyte photodestruction
2008 | Article
Int. Conf. “Biotechnology and Helath” – 2 & DAAD Alumni Seminar, April 21-25, 2008,
p.91-98
Vardapetyan H.R. , Martirosyan A.S. , Tiratsuyan S.G. , Hovhannisyan A.A. , Marutyan S.V.
Investigation of citotoxic and photodynamic activity of hypericin
2006 | Article
Blood, v.4, #2, p.16-20, 2006
Vardapetyan H.R., Tiratsuyan S.G. , Hovhannisyan A.A., Hunanyan L.S., Martirosyan A.S., Ghazaryan R.K., Ghambaryan S.S., Gyulkhandanyan G.V.
Study of photodynamic activity of hypericin and synthetic photosensitizers on haemolysis of erythrocytes in vitro
2006 | Article
Proc. of SPIE, 2006, V.608706, p.1-8
Vardapetyan H.R., Martirosyan A.S., Tiratsuyan S.G. , Hovhannisyan A.A., Marutyan S.V.
Investigation of citotoxic and photodynamic activity of hypericin
2006 | Article
J. Blood, 2006, №2 (4), p.16-21
Vardapetyan H.R., Tiratsuyan S.G. , Hovhannisyan A.A., Martirosyan A.S.
Initiation biosynthesis of hypericin and its derivatives in cell cultures of hypericum perforatum
2005 | Article
In book “Biotechnology and Health”, Yerevan, “Lucky Print”, 2005, p.66-73
Vardapetyan H.R., Gonyan S.A., Tiratsuyan S.G.
Connection of electrokinetic properties of isolated rat liver hepatocites with their functional activity
2001 | Article
Biophysics, 2001, v. 46, N 2, p. 271-274
Vardevanyan P.O., Boyajian B.G., Vardevanyan A.O., Tiratsuyan S.G. , Nerkararyan A.V.
Phospholipid fraction of chromatin of wheat germ during germination
1998 | Article
Plant Physiology, Moscow, 1998, v. 45, N 6, pp. 919-921
Vardapetyan H., Kirakosyan A., Tcharchoglian A., Tiratsuyan S. , Alexanyan A.
Fusing of wheat and amaranth proto¬plasts and callus formation from wheat and amaranth interfamily hybrids
1998 | Article
Russian Journal of Plant Physiology, 1998, v. 45, N 5, p. 725-729
Фосфолипидные фракции хроматина зародышей пшеницы при прорастании
1998 | Article
Физиология растений, Москва, 1998, т. 45, N 6, с. 919-921
Vardapetyan H., Maitesyan Y., Tiratsuyan S. , Vardevanyan P.
Differential reassociation curves in an investigation of the structure of the genome
1997 | Article
Biophysics, v. 1997, 42, N 4, p.999-1001
Vardapetyan H.R., Tiratsuyan S.G. , Vardevanyan P.O. , Bojagyan B.G., Panosyan G.A.
Phospholipid content of germinating wheat embryo
1996 | Article
Plant Physiology, 1996, v. 4, N 4, p. 616-619
Vardapetyan H.R., Tiratsuyan S.G. , Gonyan S.A.
Electrokinetic properties of isolated liver hepatocites during their activity changes
1996 | Article
Plant Physiology, 1996, v. 4, N4, p. 616-619
Vardapetyan H.R., Tiratsuyan S.G. , Vardevanyan P.O. , Bojagyan B.G., Panosyan G.A.
Study of grow wheat embryo oligonucleosomes fortified with transcriptionally active genes
1995 | Article
Plant Physiology, 1995, v. 42, N 2, p. 290-294
H. R. Vardapetian, A. B. Kirakossian, S. G. Tiratsuyan , G. H. Panossian
Параметры роста клеточных культур некоторых сортов пшеницы (Ցորենի որոշ սորտերի բջջային կուլտուրաների աճի պայմանները)
1994 | Article
ԵՊՀ Գիտական տեղեկագիր, Բնական գիտություններ, 1994, #1, էջ 80-87 (ռուսերեն)
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Поверхностный заряд изолированных ядер гепатоцитов при измерении их функциональной активности
1993 | Article
Биофизика, т.58, 1993, N5, с. 887-888
Vardapetyan H.R., Gonyan S.A., Tiratsuyan S.G.
Surface charge of isolated hepatocites nuclei during their activation measurements
1993 | Article
Biophysics, 1993, v. 38, N 5, p. 887, (IF 1.857)
Vardapetyan H.R., Tiratsuyan S.G. , Galstyan R.G., Shbib G.H., Davtyan M.A.
Transcription and circular dichroism at rat liver chromatin activation
1990 | Article
Questions of Med. Chemistry, 1990 (IF 0.23)
Davtyan N.A. , Tiratsuyan S.G., Vardapetyan H.R., Davtyan M.A.
The influence of gibberellins on nucleic acids in isolated nuclei of wheat embryo during germination
1990 | Article
Plant Physiology, v. 37, N 1, p. 177, 1990. (IF 0.492)
Изменения в хроматине печени крыс при введении смеси аминокислот
1987 | Article
Биохимия, 1987, т.52, N5, с.737-742
Вардеванян П.О. , Вардапетян Г.Р., Вардеванян А.О., Тирацуян С.Г. , Паносян Г.А.
Изменения во фракционном составе гистонов изолированных зародышей пшеницы при прорастании
1986 | Article
Физиология растений, 1986, т.33, N1, с.121-126
Vardevanyan P.O. , Panosyan G. , Vardapetyan H., Tiratsuyan S.G. , Babayan Yu.
Structural changes in wheat DNA during germination
1983 | Book
Studia biophysica 1983, 97, N3, s. 209-212
Изменение в хроматине при прорастании и обработке гиббереллином изолированных зародышей пшеницы
1982 | Article
Докл. АН СССР, 1982, 265, N3, с. 765-768