Ֆիզիկայի ֆակուլտետ
Faculty of Physics
The process of training specialists in the field of physics and mathematics began in 1922 in YSU.:
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Ishkhan V. Vardanyan

Assistant | Chair of Molecular Physics
Education
2009 - 2012: PhD student, Molecular Physics Department, Faculty of Physics, Yerevan State University
2007 - 2009: Master student, Faculty of Physics, YSU
2003 - 2007: Bachelor student, Faculty of Physics, YSU

Academic degree
Doctor of Philosophy (Ph.D.) in Physics, “Interaction of porphyrins with tRNA”, 051 Specialized Council at YSU, 2012

Professional experience
Since 2017: Head of Scientific Policy Department
2016 - 2017: Head of Scientific Management Department
2014 - 2015: Head of Scientific Management Division
02.07.2018 - 31.08.2018: Invited researcher at the Center CIC BiomaGUNE, San Sebastian, Spain
01.08.2017 - 31.08.2017: Invited researcher at the Center CIC BiomaGUNE, San Sebastian, Spain
01.07.2016 - 31.08.2016: Invited researcher at the Institute for Medical Physics and Biophysics, Leipzig University, Germany
08.06.2015 - 08.08.2015: Invited researcher at the Institute for Medical Physics and Biophysics, Leipzig University, Germany
13.04.2014 - 25.04.2014: Invited researcher at the Institute for Medical Physics and Biophysics, Leipzig University, Germany
2014: Researcher, “Physics of Macromolecules” Laboratory, Department of Molecular Physics, Faculty of Physics, YSU
15.10.2013 - 15.12.2013: Invited researcher at the Institute for Medical Physics and Biophysics, Leipzig University, Germany
Since 2010: Assistant Professor, Department of Molecular Physics, Faculty of Physics, YSU.
2009 - 2014: Junior Researcher, “Physics of Macromolecules” Laboratory, Department of Molecular Physics, Faculty of Physics, YSU.
2006 - 2009: Laboratory assistant, “Physics of Macromolecules” Laboratory, Department of Molecular Physics, Faculty of Physics, YSU

Social experience
2014: Founder and Chairman of Armenian Scientific Union
2011: Member of YSU young scientists’ society
2008 - 2010: Chairman of student’ scientific society of Physics’ Faculty, YSU

Academic courses
"Molecular Physics" for 1-st year bachelor students, YSU.
“DNA Sequencing” for Master program, YSU.

Scale of professional interests
The investigation of thermostability and conformation of biopolymers in different condition (acidic and alkaline pH, mono- and bivalent metal ions). Biopolymer-legends interaction. Membrane transport. Anomalous diffusion. Diffusion of nanoparticles in polyelectrolyte multilayers assembled by LbL technique

Participation in grant projects
2018 - 2020: Grant 18T-1F055 Urea induced conformational transitions of human telomeric DNA. supported by SCS, MoES RA
2015 - 2019: Horizon 2020 HYMADE project H2020-MSCA-RISE-2014- GA nº645686
2014 - 2017: Tempus VERITAS project
2015 - 2017: Grant 15T-1F048 Physical characterizations of biological function of human telomeric DNA, supported by SCS, MoES RA
2013 - 2015: Grant 13-1F094 The investigation of selectivity of binding of new biologically active metalloporphyrins with DNA and polynucleotides, supported by SCS, MoES RA
2011 - 2013: Armenian Belarusian grant 11РБ-017 supported by State Committee of Science, MoES RA
2010: “Young Scientists’ research support program-2010” «11A-1f040»
2008: ANSEF 08

Membership
Membership of Biophysical Society (USA)
Membership of Armenian Association of Biochemists

Awards received
2012: Biophysical Society Travel Award
2010: Prize of the President of the Republic of Armenia in the field of IT in the category of “the best PhD student”
2009: “The best master’s thesis” named after Norayr Kocharyan.

Languages
Armenian, Russian, English

ishkhan@ysu.am

Latest Publications (36)
The influence of urea on G-quadruplex and i-motif structures in complementary DNA sequences (Միզանյութի ազդեցությունը i-մոտիֆ և G-քուադրուպլեքս կառուցվածքների վրա ԴՆԹ-ի կոմպլեմենտար հաջորդականություններում)
2020 | Article
ԵՊՀ Գիտական տեղեկագիր, Ֆիզիկա և մաթեմատիկա, 2020, հ. 54, #2, էջ 115-122
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Ishkhan Vardanyan , Zaven Navoyan, Sergio Enrique Moya, Valeri Arakelyan , Edwin Donath
Flow Cytometry Study of the Non-Fickean Diffusion of Small-Charged Molecules in Poly(diallyl dimethyl ammonium chloride)/Poly(styrene sodium sulfonate) Multilayers: Impact of the Layer Number, Top Layer, and Concentration of Diffusing Molecules
2019 | Article
J. Phys. Chem. B, 2019, 123 (9), pp. 2182–2189
E.Donath, I. Vardanyan , S. Meyer, R. A. Murray, S. E. Moya, Z. Navoyan, V. Arakelyan
Atypical Diffusion Monitored by Flow Cytometry: Slow Diffusion of Small Molecules in Polyelectrolyte Multilayers
2018 | Article
Nanoscale, 2018,10, pp. 765-772
Yeva B. Dalyan , Ishkhan Vardanyan , Lusine Aslanyan, Tigran V. Chalikian, Jordan Ko, Byul G.Kim
Effect of urea on G-quadruplex stability
2017 | Article
Journal of Physical Chemistry B. 2017, 121, pp. 6511-6519
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Thermodynamics of interaction of meso-tetra-(4Noxyethylpyridyl) porphyrin and its Cu(II)- and Co(II)- containing derivatives with A and B forms of DNA
2017 | Article
Journal of Porphyrins and Phthalocyanines, 2017, Vol. 21, Issue 11, 731-738 pp.
The investigation of sodium-induced G-quadruplex stability and thermodynamics in urea solutions
2015 | Thesis
International Symposium and Young Scientist School on Disordered and Ordered Materials Analysis and Characterization, 24-30 September 2015, Yerevan, Book of Abstracts, p.42
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The Influence of the Form of tRNA on Complex Formation with Porphyrins
2014 | Thesis
Biophysical Journal, Vol. 106, Issue 2, p. 282a (2014)
The peculiarities of complex formation of porphyrins with transfer RNA
2014 | Thesis
FEBS Journal, Vol. 281, Iss. s1, p. 399-400 (2014)
The interaction of Zn metalloporphyrin with different forms of tRNA
2013 | Thesis
Biophysical Journal, Vol. 104, Issue 2, S1, p. 263a, (2013)
The interaction of porphyrins with different forms of tRNA
2013 | Thesis
International Conference “Physical Concepts of Nucleic-Acid Structure and Behavior” May 27-29, 2013, Yerevan, Armenia , Abstracts, p. 27
Interaction of Porphyrins with tRNA.The influence of Ionic Strength
2012 | Thesis
Biophysical Society 56th Annual Meeting, February 25-29, 2012, San Diego, USA, Abstract issue, Biophysical Journal, Vol. 102 Iss. 3, S1, p. 635a. (2012)
The interaction of ZnTOEPyP4 porphyrin with tRNA. The influence of ionic strength
2012 | Article
Biolog. Jour. of Armenia, 64(1) p. 105-107 (2012)
Մոլեկուլային ֆիզիկա
2012 | Book
Լաբորատոր աշխատանքների ձեռնարկ. Մաս I (վերահրատ.)// ԵՊՀ, Երևան, 2012, էջ79
Варданян И.В. , Галюк Е.Н, Ландо Д.Ю., Далян Е.Б
Взаимодействие металлопорфирина CuTOEPyP4 с транспортной РНК
2011 | Article
Вестник МАНЭБ, Том 16 No5, вып. 2, с. 26-30, (2011)
Влияние рН на взаимодействие TOEPyP4 с тРНК и ДНК
2010 | Article
Юбилейная научная сессия СНО посвященная 90-летию ЕГУ,11-15 мая 2009г. Сборник Статей, Том 1, с. 145-149 (2010)
The influence of pH on Binding of Zn-meso-tetra-(4N-hydroxyethyl-pyridyl) porphyrin with tRNA
2010 | Thesis
An International Symposium on “Solvation and Ionic Effects in Biomolecules: Theory to Experiment”, May 17-21, 2010, Tsakhkadzor, Armenia , Abstracts, p. 40.
Dalyan Y.B. , Vardanyan I.V. , Chavushyan A.S., Balayan G.
Peculiarities of Interaction of Porphyrins with tRNA at Low Ionic Strength
2010 | Article
J. of Biomol. Structure & Dynamics, v.28, N.1, p.123-131, 2010
Interaction of Zn-mesotetra-(4N-hydroxyethylpyridyl) porphyrin with tRNA from E.Coli.The influence of pH
2009 | Thesis
International Conference “Biotechnology and Health”-3 & DAAD Alumni seminar, October 15-17, 2009, Yerevan, Book of Abstract, p. 111
Y. Dalyan , I. Vardanyan , A. Chavushyan
Peculiarities of Interaction of Porphyrins with tRNA
2009 | Article
Abstracts of Albany 2009: 16th Conversation. June 16-20, Albany, New York, USA, Abstract #63. J Biomol Struct Dyn 26, 787-927 (2009)
Մոլեկուլային ֆիզիկա
2009 | Book
Լաբորատոր աշխատանքների ձեռնարկ. Մաս II // ԵՊՀ, Երևան, 2009, էջ24
ArakelyanV.B., Aramyan K.S., Arustmyan V.M, Gevorgyan H.K., Karamyan K.K. , Vardanyan V.I., , Potikyan G.G.
Isotherms of particle adsorbtion on membranes on account of adsorption center changes
2009 | Article
Procedings of the Yerevan State Uneversity. Physycal and Mathematical Sciences. 2009, No1, p.49-53
Влияние pH на взаимодействие CuTOEPyP4 с ДНК (pH-ի ազդեցությունը ԴՆԹ-ի հետ CuTOEPyP4-ի փոխազդեցության վրա)
2008 | Article
ԵՊՀ Գիտական տեղեկագիր, Բնական գիտություններ, 2008, #3, էջ 97-100 (ռուսերեն)
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The influence of рН on the interaction of CuTOEPyP4 with DNA
2008 | Article
Proceedings of the YSU, 2008, N. 3, p.97-100. (in Russian)
A.A. Ghazaryan, V.I. Vardanyan , L.R. Aloyan , M.A. Paytyan, E.B. Dalyan
The role of hydratation in “entropic” interaction of porphyrins with DNA
2008 | Thesis
International Conference of Modern Problem of Chemical Physics, Yerevan, Armenia, book of Abstract, p.112 (2008)
Effect of modification of porphyrins on interaction with DNA. The influence of ionic strength
2008 | Thesis
International Conference on “Modern problems of Chemical Physics, October 21-24, 2008, Yerevan, Book of Abstracts, p. 108.
Interaction of mesotetra (4N-hydroxyethylpyridyl) porphyrin with tRNA from E.Coli
2008 | Article
International Conference “Biotechnology and Health”-2 & DAAD Alumni seminar, April 21-25, 2008, Yerevan, Book of Abstract, p.158-159
Влияние рН на взаимодействие CuTOEPyP4 с ДНК
2008 | Article
Ученые Записки ЕГУ, No 3, с.97-100 (2008)
J. Monaselidze, G. Majagaladze, Sh. Barbakadze, D. Khachidze, M. Gorgoshidze, Y. Kalandzdze, S. G. Haroutiunian , Y. B. Dalyan , V. I. Vardanyan
Microcalorimetric Investigation of DNA, poly(dA)poly(dT) and poly[d(A C)]poly[d(G T)] melting in the presence of Water Soluble (Meso tetra (4 N oxyethylpyridyl) Porphyrin) and its Zn Complex
2007 | Article
Journal of Biomol. Structure & Dynamics, 2007, v. 25, No. 4, p. 419-424
The Influence of ionic strength on the interactionof Porphyrins with DNA
2007 | Article
Vestnik SPSU, V 4, N2, pp. 48-52 (2007)
The influence of ionic strength on the binding of porphyrins with DNA
2007 | Article
Vestnik SPbSU.Ser.4 Physics, Chemistry, No. 2, p.48-52, 2007
Interaction of Porphyrins with DNA. Effect of Central metal and Peripheral Substituents
2006 | Thesis
XIII Symposium of intermolecular interaction and conformations of molecules, Saint -Petersburg, Russia, book of Abstract, p.181 (2006)
Մոլեկուլային ֆիզիկա
2006 | Book
Լաբորատոր աշխատանքների ձեռնարկ. Մաս I // ԵՊՀ, Երևան, 2006, էջ72
A. A. Ghazaryan, Y. B. Dalyan , G. Haroutiunian, V. I. Vardanyan , R. K. Ghazaryan, T. V. Chalikian
Thermodynamics of Interactions of TAlPyP4 and AgTAlPyP4 Porphyrins with Poly(rA) poly(rU) and Poly(rI)poly(rC) Duplexes
2006 | Article
J. of Biomol. Structure & Dynamics, v.24, No.1, p.67-74, 2006
Interaction of Zn-containing meso-tetra-(3N-pyridyl) porphyrins with DNA. Effect of Peripheral Substituents.
2005 | Thesis
International Symposium on Hydration and Thermodynamics of Molecular Recognition, Tsakhadzor, Armenia, Abstracts, p. 55 (2005)
The effect of peripheral substituent on interaction of meso-tetra-(3N-pyridyl)porphyrins with DNA
2005 | Thesis
European Biophysics Journal, Vol.34, No.6, p. 667 (2005)
Асланян В. М., Морозов В. Ф. , Варданян В. И. , Бархударян В. Г. , Аветисян М. Г., Оксузян К. А., Фаршян Г. С.
Способ ускоренных испытаний полиэтилена и изделий на его основе
1980 | Article
Авт. свид. No. 2985-884, (СССР), 1980