Ֆիզիկայի ֆակուլտետ
Faculty of Physics
The process of training specialists in the field of physics and mathematics began in 1922 in YSU.:
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Samvel G. Haroutiunian

Professor | Chair of Molecular Physics
Education
1977: Graduated from Faculty of Physics, Yerevan State University

Academic degree
Candidate of phys. - math. sci. (03.00.02-Biophysics) - “The influence β-alanine and γ –ABA on structure and stability of DNA”, 1984, Institute of Physics of Georgian Academy of Science, Tbilisi.
Doctor of phys. - math. sci.(01.00.07 - Solide State Physics and 03.00.02-Biophysics) - “The influence of ligands on DNA as an one dimensional”, 1993, Institute of Applied Problem of Physics of Armenian Academy of Science, Yerevan.

Professional experience
2007: Chairman of Committee of Science of RA
2006 - 2007: Vice Rector of YSU
2000 - 2006: Dean of Faculty of Physics of YSU
1994 - 2000: Head of Department of Molecular Physics, Faculty of Physics, YSU
1992 - 1994: Head of laboratory of Macromolecular Physics on Department of Molecular Physics, Faculty of Physics, YSU
1991 - 1992: head Investigator of laboratory of Macromolecular Physics on Department of Molecular Physics, Faculty of Physics, YSU
1988 - 1991: Visiting professor at the University of Florence, Italy
1985 - 1988: Senior Scientific Researcher of laboratory of Macromolecular Physics on Department of Molecular Physics, Faculty of Physics, YSU
1983 - 1985: Junior Scientific Researcher of laboratory of Macromolecular Physics on Department of Molecular Physics, Faculty of Physics, YSU
1981 - 1983: Senior Lab. Assistant of Department of Molecular Physics, Faculty of Physics, YSU
1977 - 1980: PhD student of Department of Molecular Physics, Faculty of Physics, YSU

Academic courses
"Actual problems of physics of macromolecules " and "DNA-ligand interaction" for 1-st year master students of YSU,
"Physics of Biopolymers" for postgraduate students, YSU

Scale of professional interests
The investigation of selectivity of interaction of low molecular ligand with DNA. Determination of molecular mechanisms of interaction of DNA with antitumor (cis-platin) and potential antitumor (Pt- and Ru- complexes, porphyrins and metalloporphyrins) preparations

Participation in grant projects
1994: RYX000 from International Science Foundation
1998 - 1999: CRDF #AB1-963/ NFSAT #ACB-014-98
1999 - 2000: ISTC #A-301.1
2000 - 2001: CRDF #AB2-2006
2002 - 2004: NFSAT #MB 078/CRDF #12027
2002 - 2006: ISTC A-773
2002 - 2007: ISTC #A-301.2
2003 - 2004: NATO LST.CLG.979777
2011 - 2013: Armenian-Belarus grant, #11РБ-017
2013 - 2015: Grant of SCS RA #13-1F094

Professional membership
Vice Chairmen of Special Council 021 High Attestation Commission at Institute of Applied Problem of Physics of Armenian Academy of Science
Member of the 051 - “Biophysics” Special Council of High Attestation Commission of Armenia

Awards received
2009 Gold Medal of YSU, RA
2009 Medal of S.P.Korolev, RF
2009 Honor of Prokhorov, RF
2014 Medal of V.Sargsyan, RA

Languages
Armenian, Russian, English, Italian

sharout@ysu.am

Плавление ДНК опуxоленоcящиx кpыc, леченыx мезо-тетpа(4-n-гидpокcиэтилпиpидил)поpфиpином и его AG-, ZN-, CO-пpоизводными
2017 | Article
Биофизика. 2017, 62, 3, стр. 458–463
N. H. Karapetyan , A. L. Torosyan, M. Malakyan, S. A. Bajinyan, S. G. Haroutiunian
Investigation of irradiated rats DNA in the presence of Cu(II) chelates of amino acids Schiff bases
2016 | Article
Journal of biomolecular structure & dynamics. 2016, 34(1), 177-183 pp.
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V. M. Tsakanov , R. M. Aroutiounian , G. A. Amatuni, L. R. Aloyan , L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan , H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian , V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh.Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, G. S. Zanyan
AREAL low energy electron beam applications in life and materials sciences
2016 | Article
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2016, Volume 829, 248-253 pp.
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The features of complex formation of poly(dI-dC)2with porphyrins
2015 | Thesis
Albany 2015:19th Conversation Journal of Biomolecular Structure and Dynamics, V.33, S.1., 2015, p. 85. DOI:10.1080/07391102.2015.1032765
The features of complex formation of poly(dI-dC)2 with porphyrins
2015 | Thesis
J. Biomolecular Structure and Dynamics, Vol. 33, S1, No.132, p.85, (2015)
Development of viscometric methods for studying the interaction of various porphyrins with DNA
2014 | Article
Part I: meso-tetra-(4N-hydroxyethylpyridyl) porphyrin and its Ni-, Cu-, Co- and Zn- containing derivatives. Journal of Porphyrins and Phthalocyanines 2014 18:07, 594-599. DOI: 10.1142/S1088424614500357
Development of viscometric methods for studying the interaction of various porphyrins with DNA. Part I: meso-tetra-(4N-hydroxyethylpyridyl) porphyrin
2014 | Article
J. Porphyrins and Phthalocyanines, N 18, p. 594–599, (2014)
Самвел Геворгян , Анатолий Арабский, Самвел Арутюнян , Феликс Дедученко, Сергей Харьков
Обеспечение техногенной безопасности: есть решение!
2013 | Article
Комплексная Безопасность Отечества (Информационно-аналитический журнал Парламентского Центра Российской Федерации ),2013, № 2(3), стр. 39-41
D.Y. Lando, I.E.Grigoryan, E.N. Galyuk, A.S. Fridman, Y.B. Dalyan , S.G. Haroutiunian
Kinetics of DNA thermal stability in the presence of cisplatin
2013 | Article
Biological Journal of Armenia, 3(65), p. 14-22, (2013)
D.Y. Lando, I.E. Grigoryan, A.S. Fridman, E.N. Galyuk, Y.B. Dalyan , S.G. Haroutiunian
Evaluation of errors in determination of DNA melting curve registered with differential scanning calorimetry
2013 | Article
Biological Journal of Armenia, 2(65), p.6-12, (2013)
Karapetyan N. H. , Malakyan M. H., Bajinyan S. A., Torosyan A. L. , Grigoryan I. E., Haroutiunian S. G.
Influence of Amino Acids Shiff Bases on Irradiated DNA Stability In Vivo
2013 | Article
Cell biochemistry and biophysics. 2013, 67,1137-1145 pp.
D.Y. Lando, C.L. Chang, I.E. Grigoryan, S.G. Haroutiunian , Y.B. Dalyan , C.-K. Hu
A Computer program for differential scanning micro- and nano- calorimeters
2012 | Article
The International Scientific Conference “Molecular, Membrane and Cellular bases of functioning biosystems and the X Congress of Belarusian Public Association of photobiologists and biophysicists”, June 19-21, Minsk, Belarus, 2012, № 2, p. 288-290
Arakelyan V. , Harutyunyan S. , Andriasyan V., Arakelyan H.
Isotherm of Ligand Adsorption on DNA at Multiplicative Noise
2012 | Article
J. Biomol. Struct. Dyn., 2012, v.30, N2, p. 217-222
Comparative analysis of the effects of platinum compounds on thermostability of DNA (ԴՆԹ-ի ջերմակայունության վրա պլատինային միացությունների ազդեցության համեմատական ուսումնասիրություններ )
2011 | Article
ԵՊՀ գիտական տեղեկագիր, Ֆիզիկա և մաթեմատիկա, 2011, #3, էջ 52–57
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I.E. Grigoryan, S.G. Haroutiunian
Comparison of the effects of two platinum coordination complexes on the thermostability of DNA
2010 | Thesis
“Solvation and Ionic Effects in Biomolecules: Theory to Experiment”, May 17-21, 2010, Tsakhkadzor, Armenia, Abstract Book, p. 65
Y.Dalyan , L.Abgaryan, G.Sarkisyan, S.Haroutiunian
Comparative analysis of the effects of Cu and Ni ions on the thermostability of DNA
2008 | Article
Electronic Journal of NAS of RA, 2(11), 2008, p.7-10
J. Monaselidze, G. Majagaladze, Sh. Barbakadze, D. Khachidze, M. Gorgoshidze, Y. Kalandzdze, S. G. Haroutiunian , Y. B. Dalyan , V. I. Vardanyan
Microcalorimetric Investigation of DNA, poly(dA)poly(dT) and poly[d(A C)]poly[d(G T)] melting in the presence of Water Soluble (Meso tetra (4 N oxyethylpyridyl) Porphyrin) and its Zn Complex
2007 | Article
Journal of Biomol. Structure & Dynamics, 2007, v. 25, No. 4, p. 419-424
S.Haroutiunian , Y.Dalyan , A.Ghazaryan, T.Chalikian
Thermodinamic profile of interaction of porphyrins with nucleic acids
2007 | Article
Brilliant Light in Life and Material Science, V. Tsakanov & H.Wiedemann (eds), 2007, Springer, p. 213-218
, Y.Dalyan , S.Haroutiunian , A.Tikhomirova, N.Taulier, J.W. Wells, T.V.Chalikian
Thermodynamics of Interactions of Water-Soluble Porphyrins with RNA Duplexes
2006 | Article
J. Amer. Chem. Soc., 2006, 128, No. 6, p.1914-1921
A. A. Ghazaryan, Ye. B. Dalyan , S. G. Haroutiunian , T. V. Chalikyan
Спектральное исследование взаимодействий TAlPyP(4) и AgTAlPyP(4) с poly(rG)poly(rC), poly(rI)poly(rC) и poly(rA)poly(rU) (TAlPyP(4)-ի և AgTAlPyP(4)-ի հետ poly(rG)poly(rC)-ի, poly(rI)poly(rC)-ի և poly(rA)poly(rU)-ի փոխազդեցությունների սպեկտրալ ուսումնասիրությունը)
2005 | Article
ԵՊՀ Գիտական տեղեկագիր, Բնական գիտություններ, 2005, #3, էջ 73-79 (ռուսերեն)
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Interaction of Co-containing meso-tetra-(N-pyridil) porphyrins with DNA
2005 | Thesis
Int. Symposium on Hydration and Thermodynamics of Molecular Recognition, Tsakhkadzor, Armenia, Mar. 1-5, Book of Abstracts, 2005, p.54
Особенности комплексообразования макромолекул ДНК с низкомолекулярными лигандами (ԴՆԹ-ի մակրոմոլեկուլի կոմպլեքսառաջացման առանձնահատկությունները ցածրմոլեկուլային լիգանդների հետ)
2004 | Article
ԵՊՀ Գիտական տեղեկագիր, Բնական գիտություններ, 2004, #3, էջ 3-34 (ռուսերեն)
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The peculiarity of complexation of DNA macromolecule with low molecular ligands
2004 | Article
Scientific Reports of YSU, 2004, v.3, No.205 p.3-34 (in Russian)
Ligand Binding With Continuous Modification of Binding Sites
2004 | Article
J. Biomol. Struct. Dyn., 2004, v.22, N2, p. 245-252
Binding of New Meso-Tetra-(3N-Pyridil) Porphyrins to DNA
2003 | Thesis
HUPO 2nd Annual and IUBMB XIX World Congress, October 8-11, Monreal.Molecular and Cellular Proteomics, 2003. v.2, # 9, p.972
Melting of complexes of DNA-cis-DDP in acidic environment
2003 | Article
Experimental and Molecular Medicine, 2003, v. 35, N 6, pp. 534-537
Haroutunian T.S. , Sarkisyan Sh.S., Antonyan A.P., Haroutunian S.G. , Dalyan Y.B , Vardevanyan P.O
Melting of complexes of DNA-cis-DDP in acidic Media
2003 | Thesis
J. Biomol. Struct. & Dyn. 13th Conversation, Albany, USA, 2003, v. 20, N 6, p. 886
Adsorption of ligands on macromolecules in the fluctuating medium
2002 | Article
J. Biomol. Struct. & Dyn., 2002, v. 20, N 1, p. 1-5
Adsorption of ligands on macromolecules in the fluctuating medium
2002 | Article
J. Biomol. Struct. Dyn., 2002, v.20, N1, p. 125-130
Y. B. Dalyan , S. G. Haroutiunian , G. V. Ananyan , V. I. Vardanyan, D. Y. Lando, V. N. Madakyan, R. K. Kazaryan, L. Messori, P.L. Orioli, A. S. Benight
Interactions of Meso-tetra-(4-N-oxyethylpyridyl) Porphyrin, Its 3-N Analog and Their Metallocomplexes with Duplex DNA
2001 | Article
Journal of Biomol. Structure & Dynamics, 2001, v. 18, 677-687
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Комплексообразование металлопорфиринов с ДНК. Эффект центрального металла
2001 | Thesis
II Межд. Симпозиум “Проблемы биохимии, радиационной и космической биологии” посвященной памяти акад. Н.М.Сисакяна. Москва, Дубна, 29-31 мая 2001, Тезисы докладов, с. 74
The structural peculiarities of some DNA – porphyrin complexes
2000 | Thesis
Int. Conf.DNA Conformation, Modification and Recognition in Biomedicine, 2000, Jule 2-5 Brno, Chech. Republic, Book of Abstracts, p.76
L.Messori, A.Casini, D.Vullo, Y.B.Dalyan , S.G.Haroutiunian , P. Orioli
Effect of two representative antitumor ruthenium(III) complexes on thermal denaturation profiles of DNA
2000 | Article
Inorganica Chimica Acta, 2000, 303, p. 283-286
Dalyan Y. B. , Haroutiunian S. G. , Ananyan G. V. , Sahakyan L.A, Madakyan V. N, Kazaryan R. K.
The structural properties of DNA–Metalloporphyrin complexes
1999 | Thesis
5-th Int. Symp. On Applied Bioinorganic Chemistry (5ISASC), 1999, 13-17 April, Corfu, Greece, Book of Abstracts, p.281
The Specific Influence of External Medium on Order-Desorder Transition of DNA
1998 | Article
Int. Symp.Yerevan, 1998
Haroutiunian S.G. , Dalyan Y.B. , Morozov V.F. , Mamasachlissov Eu.Sh. , Shahinian M.S., Akhrem A.A., Lando D.Yu., Messori L., Orioli P.
Influence of cis- and trans-diamminedichloroplatinum(II) binding on the helix-coil transition of DNAs with different GC-content
1998 | Article
Inorganica Chimica Acta, 1998, 275-276, 510-514
Haroutiunian S.G , Mamasakhlissov Eu.Sh. , Dalyan Y.B. , Morozov V.F. , Khachikyan R.E., Vardevanyan P.O., Karapetyan A.T, P.Oriօli, B.Bruni
The modification of the spatial structure of DNA in its complexes with cis-DDP
1997 | Article
Biophysics 1997, 42, 372-377. (in Russian)
Haroutiunian S.G. , Vardevanian P.O. , Dalian E.B. , Antonian A.P., Karapetian A.T., Terzikian G.A.
DNA modification in DNA-cis-platinum complexes
1995 | Thesis
Journal of Biomol. Structure & Dynamics, 1995, 12, 86
S.G. Haroutiunian , P.O. Vardevanian , E.B. Dalian , A.T. Karapetian , G.A. Terzikian , N.H.Karapetian
The possible Structure DNA modifications in the presense of cisplatinum
1995 | Article
Int. Conf. on Molecular Structural Boilogy, Viena, 1995
Theoretical and experimental study of DNA helix-coil transition in acidic and alkaline medium
1994 | Article
J. of Biomol. Structure & Dynamics, 1994, N 12, 355-362
Haroutiunian S.G. , Dalian E.B. , Khachikian R.E., Aslanian V.M.
Ionization specific influence of nitrogen bases on thermostability of AT- and GC-pairs of DNA
1990 | Article
Biophysics 1990, v.35, No.4, p.588-593. (in Russian)
Haroutiunian S.G. , Aslanian V.M., Dalyan Y.B. , Lando D.Yu., Akhrem A.A.
A new method for determining the relative effect of ligands on AT- and GC-base pairs in DNA: application to metal ions, protons and two amino acids
1990 | Article
Nucleic Acids Research, 1990, N 8, 6413-6418
Akhrem A.A. , Lando D.Yu, Haroutiunian S.G. , Dalian E.B. , Shpakovski A.G.
The helix-coil transitions in alkaline medium
1989 | Article
Molecular Biology, 1989, v.23, No.2, p.518-524 (in Russian)
Aslanian V.M., Haroutiunian S.G. , Dalian E.B. , Lando D.Yu., Shpakovski A.G.
The specific interaction of ligands on AT- and GC- base pairs of DNA
1988 | Thesis
Biophysics,1988, 33, 3, 430 (in Russian)
Конформационные особенности ДНК в водных растворах некоторых аминокислот цвиттерионного типа.
1986 | Thesis
II Республиканская конференция, посвященная проблемам физико-химической биологии. Ереван 1986
Асланян В.М., Арутюнян С.Г. , Далян Е.Б. , Бабаян Ю.С., Ананян Г.В. , Погосян М.К.
Конформационные превращения и стабильность ДНК в присутствии низкомолекулярных лигандов
1985 | Article
Межвузовский сборник научных трудов "Физика", Изд. ЕГУ, 1985, вып.5, стр.173-183