Physical characterizations of biological function of human telomeric DNA
Ministry of Education and Science of RA, State Committee of Science Contracts (thematic) funding competition in 2015, Field: Biological Sciences

Short description

Currently is formed a novel anti-cancer strategy targeted on G-quadruplex formation in selected loci of the human genome, which inhibit the synthesis of telomeres, or the expression of oncogenes in vivo. Despite the fact that the energetics of G-quadruplexes has been intensively investigated, we still know little about the balance of forces that dictate the conformational preferences of G-rich DNA sequences in the presence and absence of their complementary C-rich strands. In particular, we still have an embryonic understanding of the role of solvent (water and water-soluble co-solvents), ionic effects, the length and sequence of loops and the identity of terminal nucleotides, and the presence of complementary C-rich sequence in a monomolecular or bimolecular setting. In this proposal, we have designed an experimental strategy that aims at a step-by-step characterization of various factors contributing to G-quadruplex-to-single strand and G-quadruplex-to-double strand equilibria for a selected set of human telomeric sequences.

Project Manager
Yeva B. Dalyan, Doctor of Phys. Math. Sciences, Professor

Staff members

Ishkhan V. Vardanyan, Candidate of Phys. Math. Sciences, (PhD), Researcher,
Armen T. Hovhannisyan, Master student,
Samvel G. Haroutiunian, Doctor of Phys. Math. Sciences, Professor,
Tigran V. Chalikian, PhD, Professor, Foreign Consultant

Tel.: (+374 60) 710333
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