Dates
General information
Lab-on-chip technology has been long envisaged to have tremendous commercial potential, owing to the ability of such devices to encapsulate a full range of laboratory processes in a single instrument and operate them in a portable manner, rapidly and at low cost. In this context, new approaches to speed up microfabrication while maintaining the resolution and surface quality are of prime interest. Two-photon polymerization (2PP) based microfabrication is one of the wellknown additive manufacturing techniques providing a great compromise between the fabrication speed and its resolution. Moreover, recent research progress shows significant potential to speed up the fabrication process with up to three orders of magnitude without compromising the submicrometer resolution by shifting from point-by-point printing into layer-by-layer direct pattern writing in a photopolymer resist. Thanks to this framework, we plan to fulfill the following objectives: (1) Establish a 2PP high throughput layer-by-layer additive microfabrication platform. (2) Establish an in vitro diagnostic lab-on-chip platform based on the developed microfabrication facilities and validate it for Surface Enhanced Raman Spectroscopy (SERS) based bioidentification of hemoglobin variants for the diagnosis of diabetes.
