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    • Scientific Centers and Laboratories
      • American Studies Center
      • Psychology Research Center
      • Research Laboratory of Applied Sociology
      • Center for Mathematical and Applied Research
      • Institute for Armenian Studies
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      • Research Institute of Biology
      • Research Institute of Physics
      • Research Center for the Institute of Pharmacy
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      • Scientific and Educational Center for Control and Monitoring of the Quality of Medicines
      • Legal Clinic
      • Center for Applied Psychology
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      • Center for Russian Studies
      • Distance Learning Laboratory of Sociology
    • Column Wrapper
      • Banner
    • Administrative Divisions of YSU
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      • Center for Doctoral Education
      • General Division
      • YSU History Museum
      • Department of Energy System Operation
      • Financial Analysis Department
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  1. Main
  2. Employees
  3. Hayarpi Gevorg Javrushyan
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hg.javrushyan@ysu.am

Hayarpi Gevorg Javrushyan

Research Institute of Biology
Signal transduction and experimental pathology research group from
Group Leader

Personal information

Date of birth
1987
Education
Institution
Yerevan State University
Faculty
Biology/Biochemistry
Date
2008 - 2010
Degree name
Masters
Institution
Yerevan State University
Faculty
Biology/Biochemistry
Date
2004 - 2008
Degree name
Bachelor
Scientific Rank/degree
Institution
Yerevan State University
Date
2014
Degree name
Candidate
Scientific Supervisor
Ph.D, Professor, M.A. Davtyan
Research Topic
Influence of NO on the urea cycle
Language skills
English
Русский
Work experience
Institution
Yerevan State University
Period of time
2025 till now
Rank/degree
Signal Transduction and Experimental Pathology Research group leader
Institution
Yerevan State University
Period of time
2023 till now
Rank/degree
assistant professor
Institution
YSU
Period of time
2023 - 2025
Rank/degree
Research group leader
Institution
YSU
Period of time
2016 - 2022
Rank/degree
Junior researcher
Participation in international conferences and seminars
07/10/2024 - 12/10/2024
Erasmus+ Staff Training week "Implementation and Development of Erasmus+ (KA 1+2)"
Saarland University
Germany
31/08/2024 - 01/09/2024
Modelling immunotherapy response and toxicity in cancer” (IMMUNO-model) CA21135
Dublin City University
Ireland
Membership
Institution
The European Association for Cancer Research
Period of time
2024 till now
Institution
The Federation of the European Biochemical Societies
Period of time
2012 till now
Other information

https://www.bok.am/user/36305

Publications

- Կատեգորիա -
Article
Inhibition of the PI3K signaling pathway in cancer cells by Agrimonia eupatoria L. ethanolic extract: identification of tricoumaroyl spermidine as a potential PI3K inhibitor
Mikayel Ginovyan
Smbat Gevorgyan
Hayarpi Javrushyan
Barbara Kusznierewicz
Izabela Koss-Mikołajczyk
Naira Sahakyan
Agnieszka Bartoszek
Nikolay Avtandilyan
BMC Complementary Medicine and Therapies
2026
1-27
https://www.scopus.com/pages/publications/105029219890?origin=resultslist
Article
Evaluating the Efficacy of Polyphenol‐Enriched Plant Extracts and Pathway Modulators in the Bone Marrow to Suppress Breast Cancer Progression
Hayarpi Javrushyan
Gayane Petrosyan
Marika Mróz
Barbara Kusznierewicz
Yem Alharithi
Mikayel Ginovyan
Alina Maloyan
Nikolay Avtandilyan
The FASEB Journal
2026
e71651 - e71651
https://doi.org/10.1096/fj.202501773rrr
Conference
Immunomodulatory and Anti-Tumor Effects of Alchemilla smirnovii Juz in Experimental Breast Cancer Models
Aqsanna Gevorgyan
Arpine Hakobyan
Astghik Mkrtchyan
Nikolay Avtandilyan
Hayarpi Javrushyan
2026
69
https://www.immuno-model.eu/newss/immuno-model-final-conference-building-bridge…
Article
Elucidating the impact of Hypericum alpestre extract and L-NAME on the PI3K/Akt signaling pathway in A549 lung adenocarcinoma and MDA-MB-231 triple-negative breast cancer cells
Hayarpi Javrushyan
Mikayel Ginovyan
Tigran Harutyunyan
Smbat Gevorgyan
Zaruhi Karabekian
Alina Maloyan
Nikolay Avtandilyan
PLOS ONE
2025
e0303736
Article
ALTERATIONS IN ARGINASE ACTIVITY, NITRIC OXIDE, AND MDA LEVELS IN BONE MARROW DURING DMBA-INDUCED BREAST CANCER IN RATS
Svetlana M. Hovhannisyan
Aqsana S. Hakobyan
Arpine N. Hakobyan
Astghik A. Mkrtchyan
Hayarpi G․ Javrushyan
Proceedings of the YSU B Chemical and Biological Sciences
2025
113-121
Conference
Interconnection between hyperglycemia, cancer, and arginine metabolism: a unified therapeutic approach
E.Nadiryan
H.Javrushyan
N.Avtandilyan
2025
313 - 313
https://2025.febscongress.org/
Conference
Hypericum alpestre Inhibits PI3K/Akt/mTOR and HIF-1α Signaling While Activating Caspase-3 in MDA-MB-231 Cells: A Comparative Study with Dactolisib and Doxorubicin
H. Javrushyan
N. Avtandilyan
A. Maloyan
2025
312 - 312
https://2025.febscongress.org/
Conference
Synergistic Inhibition of HIF1α and PI3K/Akt Signaling and Activation of Caspase3 by Emodin and Metformin Combination in MDAMB231 Cells
M. Kocharyan
H. Javrushyan
N. Avtandilyan
2025
313 - 313
https://2025.febscongress.org/
Conference
Phytochemicals and Chemotherapy: Present and Future Strategy
Hayarpi Javrushyan
Edita Nadiryan
Nikolay Avtandilyan
Alina Maloyan
2025
7 - 7
https://www.santearmenieacademy.org/en/live-events/international-summit-in-immu…
Conference
Hypoxia-Linked Alterations in Arginine Metabolism and Oxidative Stress in the Bone Marrow during Breast Cancer Progression and Treatment
Hayarpi Javrushyan
Edita Nadiryan
Svetlana Hovhannisyan
Nikolay Avtandilyan
2025
6 - 6
https://www.ivb.ro/annual-conference-of-pathology
Conference
Modulating Bone Marrow Microenvironment in Breast Cancer: Impact of Combined Chemotherapy and Herbal Extracts
Edita Nadiryan
Gayane Petrosyan
Nikolay Avtandilyan
Hayarpi Javrushyan
2025
145-145
https://www.ysu.am/en/conference/869
Conference
Hypericum alpestre Extract and L-NAME Suppress PI3K/Akt Pathway and Enhance Apoptosis in Lung and Breast Cancer Cells
Svetlana Hovhannisyan
Gayane Petrosyan
Hayarpi Javrushyan
Mikayel Ginovyan
Nikolay Avtandilyan
2025
146-146
https://journals.ysu.am/index.php/jisees/issue/view/SI_1_2025
Article
Hypericum alpestre extract exhibits in vitro and in vivo anticancer properties by regulating the cellular antioxidant system and metabolic pathway of L-arginine
Mikayel Ginovyan
Hayarpi Javrushyan
Hasmik Karapetyan
Izabela Koss‐Mikołajczyk
Barbara Kusznierewicz
Anna Grigoryan
Alina Maloyan
Agnieszka Bartoszek
Nikolay Avtandilyan
Cell Biochemistry and Function
2024
1-21
Article
5-fluorouracil and Rumex obtusifolius extract combination trigger A549 cancer cell apoptosis: uncovering PI3K/Akt inhibition by in vitro and in silico approaches
Mikayel Ginovyan
Hayarpi Javrushyan
Svetlana Hovhannisyan
Edita Nadiryan
Gohar Sevoyan
Tigran Harutyunyan
Smbat Gevorgyan
Zaruhi Karabekian
Alina Maloyan
Nikolay Avtandilyan
Scientific Reports
2024
1-16
Article
Royal Jelly–Mediated Silver Nanoparticles Show Promising Anticancer Effect on HeLa and A549 Cells Through Modulation of the VEGFa/PI3K/Akt/MMP-2 Pathway
Meri Kocharyan
Syuzan Marutyan
Edita Nadiryan
Mikayel Ginovyan
Hayarpi Javrushyan
Seda Marutyan
Nikolay Avtandilyan
Applied Organometallic Chemistry
2024
1-11
Conference
Adipose Tissue Dysfunction in the Offspring of Obese Mothers
Hayarpi Javrushyan
Yem J Alharithi
Nolan Gregg
Sushil Kumar
Alina Maloyan
2024
294A
https://www.sri-online.org/events/2024
Conference
The combination of herbs and chemotherapeutic agents inhibits tumor progression via down-regulation of the TNFa-VEGFa/PI3K/Akt/NOS/COX-2-MMP-2 pathway in DMBA-induced breast cancer in rats
N. Avtandilyan
M. Kocharyan
S. Hovhannisyan
S. Gevorgyan
H. Javrushyan
M. Ginovyan
A. Maloyan
2024
276-276
https://2024.eacr.org/
Conference
Enhanced anti-inflammatory and antiproliferative effects of Inula helenium herbal extract and arginase inhibitor in breast cancer in vivo study
E. Nadiryan
H. Javrushyan
N. Avtandilyan
2024
322-322
https://2024.febscongress.org/
Article
Anti-cancer effect of in vivo inhibition of nitric oxide synthase in a rat model of breast cancer
Nikolay Avtandilyan
Hayarpi Javrushyan
Mikayel Ginovyan
Anna Karapetyan
Armen Trchounian
Molecular and Cellular Biochemistry
2023
261-275
Article
Screening revealed the strong cytotoxic activity of Alchemilla smirnovii and Hypericum alpestre ethanol extracts on different cancer cell lines
Mikayel Ginovyan
Svetlana Hovhannisyan
Hayarpi Javrushyan
Gohar Sevoyan
Zaruhi Karabekyan
Narine Zakaryan
Naira Sahakyan
Nikolay Avtandilyan
AIMS Biophysics
2023
12–22

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