General information
The project aims to introduce in Armenia the technology of stimuli-responsive polymer nanocarriers, which allows for targeted delivery and increased bioavailability of natural and synthetic compounds by controlled release depending on physiological stimuli. This technology is one of the priority directions in the field of drug delivery.
The training is planned at the Department of Pharmacy of Saarland University, Germany, in the laboratory of Professor Sanggun Lee, who specializes in the design of pH- and ROS-sensitive nanosystems. The applicant’s current scientific work, aimed at studying the anti-diabetic and anti-cancer effects of phytochemicals (emodin, pseudohypericin) and signaling pathway inhibitors (nor-NOHA, LNAME) in in vitro and in vivo models, will be combined with the experience gained during the training.
The project will also lay the foundation for the development of glucose-sensitive and hypoxia-sensitive systems, contributing to the targeted effectiveness of insulin and antiinflammatory therapies in conditions of metabolic syndrome.
