November 18, 2024 | 09:25
Research
Publications and scientific journals
International cooperation
Research focused on the development of new and safe medications
The exploration of the potential applications of newly synthesized molecules in tissue regenerative therapy, as well as the discovery of targeted drug delivery systems, represents a significant advancement in the field of science. These studies were conducted by a group of researchers from Yerevan State University (YSU) and abroad, led by Hayarpi Simonyan, Head of the Chair of Pharmaceutical Chemistry and Pharmacognosy at YSU Institute of Pharmacy. The research findings were published in the prominent international Q1 journal, "Biomolecules".
The article, published in the Q1 journal, is titled "BSA Binding and Aggregate Formation of a Synthetic Amino Acid with Potential for Promoting Fibroblast Proliferation".
Hayarpi Simonyan talked about the relevance of the article, highlighting the opportunities offered by advancing science.
Development of New Molecules for New Therapeutic Approaches
The development of methods for the synthesis of potentially pharmaceutically active new molecules and the exploration of their biological activity potential are highly relevant and pressing issues today. Therefore, the conducted research is both relevant and significant.
There is an increasing need for new, more effective, and safer medications for the treatment of various diseases, as existing drugs often have side effects or limited efficacy. Advances in science and technology provide opportunities to identify new biological targets in the human body, through which it may be possible to influence disease progression. The development of new molecules for these targets is crucial for creating new therapeutic approaches. Therefore, the development of methods for synthesizing new molecules and studying their biological activity is important for the advancement of both medicine and science.
Significance of the Research Across Various Fields
The conducted research focuses on the synthesis of biologically active, new, non-protein amino acids and the investigation of their biological activity using spectral, in silico (with IT technologies) and in vitro (experimental conditions) methods. The findings indicate that the aggregates of the amino acid under study promote fibroblast growth and may serve as potential regenerative agents. Furthermore, the ability of the synthetic amino acid to bind serum albumins highlights its potential significance in drug delivery systems.
The findings of the research will be valuable in the fields of organic chemistry, pharmaceutics, medicinal chemistry, and biomedical sciences.
Contemporary Research as a Result of International Collaboration
The research was conducted within the framework of thematic funding from the Higher Education and Science Committee of the Ministry of Education, Science, Culture and Sports of the Republic of Armenia. The study was carried out over the course of approximately one year, in two research institutes: the synthesis of the new compound was conducted at YSU Institute of Pharmacy, while the biological research was conducted at the Institute of Biostructures and Bioimaging in Naples, Italy.
The research was carried out by two scientific teams: one from YSU Institute of Pharmacy and the other from the Institute of Biostructures and Bioimaging in Naples. The Armenian team included PhD, Associate Professor Hayarpi Simonyan, PhD, Associate Professor Satenik Petrosyan, and PhD, Associate Professor Anna Mkrtchyan. The scientific advisor of the team was Doctor of Sciences, Professor Ashot Saghyan.
